Experience the timeless elegance of The De La Pena/Frank Applegate Residence, a distinguished historical treasure nestled in Santa Fe's coveted Historic Eastside. An extraordinary opportunity to own a true piece of Santa Fe history, this landmark estate sits on 1.78 acres along a private lane, just moments from world-renowned Canyon Road and its celebrated galleries, boutiques, and fine dining. Constructed in 1650, and recognized for its National Historic Status, this remarkable property was acquired in 1845 by Spanish officer Francisco de la Pea and later purchased by esteemed artist and architect Frank Applegate. Meticulously restored to honor its past while seamlessly integrating modern luxury, the estate is designed around a picturesque placita courtyard, with a stunning 5-bedroom, 7-bath main residence and a welcoming guest casita. With every detail reflecting the finest level of artisanal craftsmanship, this incomparable estate offers a custom wine cellar with refrigeration, two garages, a clay tennis court, a ramada, and a private well for irrigation. The idyllic outdoor areas offer fabulous entertaining spaces, mature trees, multiple courtyards, along with a lush lawn, portals, and an abundance of privacy. Modern amenities are seamlessly integrated into the estate with a Control 4 Smart Home operating system. With its premier location and unparalleled provenance, this estate is a rare gem for discerning buyers seeking a luxurious lifestyle in the heart of Santa Fe.